1.
Indian J Exp Biol
;
2000 Jun; 38(6): 554-8
Article
in English
| IMSEAR
| ID: sea-60353
ABSTRACT
Damage induction to tumour target cells (P815) by direct electric current (DC) was investigated. A 6 min treatment of P815 cells with DC generated decreased levels of cell viability and proliferation. The ultrastructural analysis of DC-treated cells revealed the presence of blebs, loss of cell surface filopodia, and ruptures in cell membrane. Mitochondrial alterations, swelling of cells, cytoplasmic matrix rarefaction, and cellular debri formation were also observed. The study shows that tumoural target cells can be damaged by direct electric current and this approach may provide means to understand the mechanism of tumour regression induced by electrochemical therapy.
Subject(s)
Animals , Cell Death , Cell Division , Electric Stimulation Therapy , Electricity , Mast-Cell Sarcoma/pathology , Mice , Microscopy, Electron , Tumor Cells, Cultured/ultrastructure
2.
Folha méd
;
88(5): 263-7, 1984.
Article
in Portuguese
| LILACS
| ID: lil-22880